Beckman Coulter SAMIFlex

Beckman Coulter SAMI EX Architectural Assessment

SAMI EX (formerly SAMIFlex) serves as the primary deterministic scheduler for Beckman Coulter automation lines. The architecture is engineered to eliminate stochastic variability in sample processing through rigid handshaking protocols and pre-calculated routing tables 📑. In the 2026 laboratory ecosystem, SAMI EX is deeply integrated with the DxU Intelligence platform, shifting from simple automation to predictive workflow management.

Deterministic Scheduling & Hardware Interoperability

The system operates on a high-frequency task orchestration layer that manages physical sample movement via robotic transport modules. Unlike heuristic-based engines, SAMI EX relies on deterministic logic to ensure reproducible results and strict adherence to assay timing requirements 📑.

• Dynamic Runtime Reconfiguration: Allows for the insertion of STAT samples into the workflow by recalculating the dependency graph in real-time 📑.
• Operational Latency: The software introduces a managed processing overhead during complex re-routing, though specific millisecond-level metrics remain undisclosed 🧠.
• Traceability & IVD Compliance: Maintains comprehensive audit trails for every sample movement, supporting FDA 21 CFR Part 11 and CE-IVD regulatory requirements 📑.

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DxU Intelligence & Predictive Simulation

Integration with the DxU ecosystem enables advanced modeling and real-time operational visibility.

• Workflow Simulation: Uses digital twin technology within DxU Intelligence to model laboratory throughput and identify bottleneck constraints before physical implementation 📑.
• Predictive Maintenance: Aggregates instrument telemetry to forecast hardware failures, reducing unplanned downtime across the automation line 📑.

Regulatory Compliance & Evaluation Guidance

Technical evaluators must prioritize the validation of SAMI EX within the context of IQ/OQ/PQ (Installation, Operational, and Performance Qualification) frameworks. It is critical to verify how the deterministic scheduler handles multi-vendor instrument integration via ASTM or HL7 standards. Organizations should request technical specifications for data persistence layers to ensure alignment with institutional cybersecurity policies 🌑.